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Equipoise clinical research
More research needs to be done to figure out the balance of these potential benefits and risks as well as the precise clinical utility of testosterone treatmentin both men and women.
In general, the idea that testosterone therapy can significantly reduce the risk of prostate cancer without significantly increasing the risk of developing cardiovascular or stroke causes a bit of controversy, danocrine price.
One controversial point: some believe the negative effects are largely related to the "lifestyle" component, buy anabolic steroids from india. Many men believe that testosterone therapy increases the risk of coronary heart disease and stroke because testosterone in low doses causes an increase in levels of a hormone called "DHEA, how to cycle off dianabol." It's thought this occurs because the hormone DHEA promotes atherosclerosis. One study found that over the long-term, the levels of this hormone "propelled" men to have a higher incidence of heart attacks, which "could not be explained by differences in diet or exercise." This was considered preliminary research at the time, danocrine price. Other researchers found no evidence of such a link and that there was almost no difference between men who took testosterone gel or injections and those who didn't, research equipoise clinical.
Another problem is that research suggests that DHEA might be increased in men on testosterone therapy, muubs outlet. For example in a study published last year, a group of men with lower levels of the male sex hormone testosterone were given either placebo or testosterone gel twice a week for a six-week period and then were randomized into therapy groups. The gel group did not see a reduction in cardiovascular death, death from any cause or from cancer. The low-dose testosterone group didn't see a reduction in CVD outcomes, anabolic androgenic steroids price. As noted by Professor Breslow, the data used by the study authors "did not allow for any meaningful examination of this issue."
Some of the newer studies look at more specific questions of efficacy, prednisone for muscle strain dosage. For example, for a short-term trial, the first randomized clinical trial showed that testosterone gel was much more efficacious than placebo in achieving significant decreases in the levels of total cholesterol and LDL ("bad") cholesterol, but for more than two-thirds of the men in the trial, testosterone gel failed to reach statistical significance.
These studies also show that men who start therapy at lower testosterone levels than those in the "optimal" range do not appear to be at higher health risks (such as heart disease or cardiovascular disease), equipoise clinical research.
In 2011, we reported on some of these studies and their implications for prostate cancer treatment, and how testosterone may be beneficial but also poses its own set of problems.
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